Predicting preeclampsia in early pregnancy using clinical and laboratory data via machine learning model

Table 1 Comparison of maternal obstetric characteristics and pregnancy outcome of the women who did and did not develop PE in the discovery cohort

Clinical feature		EPE (n = 25)	LPE (n = 60)	Preterm PE (n = 36)	Mild PE (n = 31)	Severe PE (n = 54)	Control (n = 289)
The onset weeks of gestation		28.94 ± 4.05	37.29 ± 1.56	32.01 ± 4.27	35.94 ± 3.79	36.45 ± 4.82
Age		33.36 ± 5.43***	32.07 ± 4.83***	32.69 ± 5.05***	32.65 ± 4.6***	32.33 ± 5.28***	29.35 ± 4.40
BMI		23.91 ± 4.17***	23.85 ± 5.24***	23.83 ± 4.26***	24.58 ± 4.2***	23.22 ± 5.22**	21.18 ± 2.87
MAP		93.64 ± 9.15***	91.28 ± 10.14***	91.76 ± 9.99***	93.14 ± 10.89***	91.15 ± 9.22***	83.42 ± 8.24
Primiparous woman	No	14	26	18	12	28	131
Primiparous woman	Yes	11	34	18	19	26	157
RPL	No	19**	54	31	27	46	269
RPL	Yes	6	6	5	4	8	19
Past medical history	No	21***	59	33**	30	50***	289
Past medical history	Yes	4	1	3	1	4	0
IVF	No	20***	49***	28***	23***	46***	284
IVF	Yes	5	11	8	8	8	5
Gestational age at delivery (weeks)		32.42 ± 4.37***	37.76 ± 1.53***	33.22 ± 3.72***	36.96 ± 2.99***	35.75 ± 3.89***	39.08 ± 0.93
Birthweight (g)		1872.22 ± 678.89***	2785.09 ± 601.70***	1982.14 ± 601.91***	2966.43 ± 544.83**	2336.98 ± 727.83***	3194.69 ± 312.72

*, **, *** denote P value < 0.05, < 0.01 and < 0.001 respectively. RPL is defined as a woman who has more than 2 miscarriages or induced abortions. Past medical history denotes a woman has at least one of the following complications: medical history of pregnancy diabetes, pre-eclampsia, family history of pre-eclampsia, chronic hypertension, systemic lupus erythematosus and antiphospholipid syndrome

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