Table 3 Generated alerts and the sensitivity, specificity, PPV, NPV and excess alerts
Drug | Alerts | Sensitivity (n1/n2; % + 95% CI) | Specificity (n3/n4; % + 95% CI) | Positive predictive value (n1/n5; % + 95% CI) | Negative predictive value (n4/n6; % + 95% CI) | Excess alerts (n7/n8; % + 95% CI) |
|---|---|---|---|---|---|---|
Dabigatran | 9 | 9/16; 56.3 [33.2, 76.9] | 2/2; 100.0 [34.2, 100.0] | 9/9; 100.0 [70.1, 100.0] | 2/9; 22.2 [6.3, 54.7] | 2/9; 22.2 [6.3, 54.7] |
Ciprofloxacin | 65 | 65/65; 100.0 [95.4, 100.0] | 118/118; 100.0 [96.9, 100.0] | 65/65; 100.0 [95.4, 100.0] | 118/118; 100.0 [96.6, 100.0] | 16/65; 24.6 [15.8, 36.3] |
Vancomycin | 58 | 39/39; 100.0 [91.0, 100.0] | 53/72; 73.6 [62.4, 82.4] | 39/58; 67.2 [54.4, 77.9] | 53/53; 100.0 [93.2, 100.0] | 33/58; 56.9 [44.1, 68.8] |
Dalteparin - collectively | 1086 | 1086/1086; 100.0 [99.6, 100.0] | 2408/2408; 100.0 [99.8, 100.0] | 1086/1086; 100.0 [99.6, 100.0] | 2408/2408; 100.0 [99.8, 100.0] | 432/1086; 39.8 [36.9, 42.7] |
Dalteparin - anti-Xa level | 116 | 116/116; 100.0 [96.8, 100.0] | 173/173; 100.0 [97.8, 100.0] | 116/116; 100.0 [96.8, 100.0] | 173/173; 100.0 [97.8, 100.0] | 38/116; 32.8 [24.9, 41.7] |
Dalteparin - therapeutic | 154 | 154/154; 100.0 [97.6, 100.0] | 173/173; 100.0 [97.8, 100.0] | 154/154; 100.0 [97.6, 100.0] | 173/173; 100.0 [97.8, 100.0] | 62/154; 41.0 [40.3, 48.2] |
Dalteparin - prophylactic | 816 | 816/816; 100.0 [99.5, 100.0] | 2235/2235; 100.0 [99.8, 100.0] | 816/816; 100.0 [99.5, 100.0] | 2235/2235; 100.0 [99.8, 100.0] | 332/816; 40.5 [37.2, 43.9] |