Fig. 1

Central illustration and flow chart of the study design. This figure contains the central illustration and the flow chart. Figure 1-a is a summary of the entire research, explaining the input variables and output results in the model, and the clinical significance of our study. Figure 1-b is the flow chart of this study. After enrolled all the patients matched inclusion criteria, we did the screening according to the exclusion criteria and finally included 1,600 participants