Fig. 6
From: A novel method for subgroup discovery in precision medicine based on topological data analysis
Representation of the ER+ METABRIC cohort through the Mapper graph. A The Mapper graph built using parameters identified from the hotspot detection algorithm run on METABRIC data. Each labelled node represents a group of patients with similar gene expression. The node size represents the number of patients covered by it as indicated in the top right legend. The bottom right legend describes the attribute function colouring the graph. In this instance, this is the occurrence of relapse before 10-years. The node identified as a hotspot is highlighted in red. B The dendrogram obtained from the cluster identification step of the hotspot detection algorithm. Nodes labels are coloured by attribute function. Node 2 is identified as a single cluster within the Mapper graph. C Kaplan-Meier curve differentiating RFS outcome in months between the hotspot group and the neighbourhood group of patients