Fig. 6

31 genes screened as feature values of deep neural network. (A) Heatmap of relevance showing intrinsic linear connection of 31 genes and association of their transcriptional level with TMB. (B) Coefficients of 31 features through lasso regression. The first 6 of them with coefficient over 0.1 were AC108515.1, MIR6744, AC092811.0, AC138811.2, MCUB and AACADL4, with TIMM21 exerting the least impact. (C) Bar plot of TMB in 2 transcriptional group in which samples were split by median of mRNA. *P < 0.05, **P < 0.01, ***P < 0.001