Fig. 3

Differentially expressed genes between high- and low-TMB group and functional enrichment analysis. AÂ Heatmap of top 40 differentially expressed genes (DEGs). BÂ GO and (C) KEGG functional analysis for 256 DEGs. BP, biological process; CC, cellular component; MF, molecular function. Gene set enrichment analysis between 2 TMB groups for (D) immunological signatures and (E) kegg pathways using software GSEA_4.1.0