Table 2 Multivariate Cox proportional hazard model of disease-specific survival and overall survival in all patients

Age (years)

< 65

Reference

——

Reference

——

≥ 65

.006

2.116

1.243

3.603

.000

4.033

2.762

5.888

Race

.287

.690

White

Reference

——

Reference

——

Black

.119

.462

.175

1.220

.874

1.045

.607

1.799

Other

.934

1.033

.482

2.215

.390

1.235

.764

1.996

Marital status

.853

.058

Not married

Reference

——

Reference

——

Married

.757

1.123

.540

2.334

.029

1.849

1.066

3.208

Unkonw

.788

.838

.232

3.027

.702

1.195

.479

2.981

Year of diagnosis

.029

.158

2001–2005

Reference

——

Reference

——

2006–2010

.008

4.624

1.498

14.278

.026

2.214

1.101

4.452

2011–2015

.007

6.761

1.672

27.341

.075

2.238

.923

5.427

2016–2019

.084

3.706

.840

16.354

.192

1.907

.723

5.033

Primary site

.157

.432

Nipple

Reference

——

Reference

——

Central portion

.993

.635

.000

4.749E + 44

.900

477.401

.000

2.847E + 44

Inner quadrant

.921

172.441

.000

4.153E + 46

.889

926.757

.000

5.502E + 44

Lower-inner quadrant

.922

167.893

.000

4.050E + 46

.894

706.937

.000

4.203E + 44

Upper-outer quadrant

.922

169.359

.000

4.074E + 46

.887

1099.677

.000

6.526E + 44

Lower-outer quadrant

.912

327.782

.000

7.890E + 46

.881

1582.618

.000

9.398E + 44

Axillary tail

.869

5453.511

.000

1.347E + 48

.866

3900.965

.000

2.369E + 45

Overlapping lesion

.923

152.386

.000

3.668E + 46

.889

943.993

.000

5.603E + 44

NA

.925

138.849

.000

3.344E + 46

.889

962.276

.000

5.712E + 44

Histologic type

.000

.000

HR-/HER2-

Reference

——

Reference

——

HR-/HER2+

.036

.177

.035

.891

.041

.294

.091

.951

HR+/HER2-

.000

.132

.057

.306

.000

.214

.112

.408

HR+/HER2+

.000

.134

.046

.392

.001

.270

.125

.582

NA

.038

.287

.088

.933

.000

.227

.103

.500

Stage

.000

.000

I

Reference

——

Reference

——

II

.002

4.317

1.701

10.957

.197

1.303

.872

1.946

III

.000

13.808

5.114

37.281

.000

3.145

1.909

5.182

IV

.000

51.387

17.045

154.918

.000

3.931

1.953

7.913

NA

.028

7.239

1.236

42.391

.163

2.126

.737

6.126

Surgery approach

.004

.000

No surgery

Reference

——

Reference

——

BCS

.001

.219

.086

.558

.000

.261

.146

.465

Mastectomy

.007

.300

.126

.714

.000

.238

.137

.414

NA

.023

.017

.001

.574

.071

.061

.003

1.270

Radiation status

No

Reference

——

Reference

——

Yes

.046

.566

.323

.991

.006

.589

.404

.859

Chemotherapy status

No

Reference

——

Reference

——

Yes

.972

.989

.550

1.780

.305

.804

.530

1.220