N,% | 2015 N = 22 | 2016 N = 67 | 2017 N = 81 | 2018 N = 116 | 2019 N = 181 | 2020 N = 100 |
---|---|---|---|---|---|---|
HCV genotype | ||||||
Genotype 1a/b/other | 2/11/0 (9.1/50.0/0) | 24/18/1 (35.8/26.9/1.5) | 23/16/3 (28.4/19.8/3.7) | 28/29/3 (24.1/25.0/2.6) | 36/52/4 (19.9/28.7/2.2) | 31/19/0 (31.0/19.0/0.0) |
Genotype 2 | 2 (9.1) | 9 (13.4) | 6 (7.4) | 5 (4.3) | 10 (5.5) | 2 (2.0) |
Genotype 3 | 3 (13.6) | 11 (16.4) | 20 (24.7) | 31 (26.7) | 56 (28.7) | 25 (25.0) |
Genotype 4 | 4 (18.2) | 3 (4.5) | 7 (8.6) | 14 (12.1) | 10 (5.5) | 7 (7.0) |
Genotype 5/6 | 0 (0) | 0 (0) | 1 (1.2) | 0 (0) | 1 (0.6) | 0 (0) |
Unkown | 0 (0) | 1 (1.5) | 5 (6.2) | 6 (5.2) | 12 (6.6) | 16 (7.0) |
Liver cirrhosis | 11 (50.0) | 12 (17.9) | 11 (13.6) | 23 (19.8) | 37 (20.4) | 24 (24.0) |
Child Pugh A | 9 (81.8) | 10 (83.3) | 8 (72.7) | 19 (82.6) | 29 (78.4) | 19 (79.2) |
Child Pugh B/C | 0 (0) | 1 (8.3) | 2 (18.2) | 3 (13.0) | 5 (13.5) | 4 (16.7) |
Unknown | 2 (18.2) | 1 (8.3) | 1 (9.1) | 1 (4.3) | 3 (8.1) | 1 (4.2) |
Comorbidities | ||||||
Chronic kidney disease | 1 (4.5) | 2 (1.5) | 0 (0) | 3 (2.6) | 1 (0.6) | 0 (0) |
Treatment status | ||||||
Treatment naïve | 8 (36.4) | 45 (67.2) | 46 (63.0) | 92 (79.3) | 150 (82.9) | 83 (83.0) |
PEG-IFN-experienced | 13 (59.1) | 18 (26.9) | 23 (31.5) | 15 (12.9) | 20 (11.0) | 12 (12.0) |
DAA-experienced | 1 (4.5) | 4 (6.0) | 4 (5.5) | 9 (7.8) | 11 (6.1) | 5 (5.0) |
DAA regimen | ||||||
ELB/GRZ | - | - | 5 (6.2) | 11 (9.5) | 29 (16.0) | 8 (8.0) |
GLE/PIB | - | - | - | 46 (39.7) | 76 (42.0) | 69 (69.0) |
OMV/PTV/RTV + DSV | 5 (22.7) | 7 (10.4) | 3 (3.7) | - | - | - |
SOF | 4 (18.2) | 2 (3.0) | - | 1 (0.9) | - | - |
SOF/DCV | 7 (31.8) | 27 (40.3) | 25 (30.9) | 6 (5.2) | - | - |
SOF/LDV | 4 (18.2) | 30 (44.8) | 32 (39.5) | 15 (12.9) | 2 (1.1) | - |
SOF/SIM | 2 (9.1) | - | 1 (1.2) | - | - | - |
SOF/VEL | - | - | 14 (17.3) | 39 (29.3) | 61 (33.7) | 19 (19.0) |
SOF/VEL/VOX | - | - | 1 (1.2) | 1 (0.9) | 12 (6.6) | 3 (3.0) |
SOF + GLE/PIB | - | - | - | 2 (1.7) | - | 1 (1.0) |
Other | - | 1 (1.5) | - | - | 1 (0.6) | - |
Addition ribavirin | 14 (63.6) | 10 (14.9) | 8 (9.9) | 2 (1.7) | 4 (2.2) | 3 (3.0) |
SVR | 21 (95.5) | 64 (95.5) | 78 (96.3) | 113 (97.4) | 173 (96.6) | 93 (93.0) |