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Table 10 Top five important pathways sorted by p-value for each gene list

From: Combining entity co-occurrence with specialized word embeddings to measure entity relation in Alzheimer’s disease

Proposed

Pathway name

Entities

Reactions

found

ratio

p-value

FDR*

found

ratio

 Nuclear signaling by ERBB4

3 / 35

0.002

5.37e-05

0.012

3 / 22

0.002

 Signaling by interleukins

7 / 640

0.046

2.60e-04

0.019

6 / 491

0.041

 MECP2 regulates transcription of neuronal ligands

3 / 61

0.004

2.74e-04

0.019

3 / 37

0.003

 Signaling by receptor tyrosine kinases

2 / 13

9.25e-04

3.41e-04

0.019

2 / 8

6.68e-04

 NRIF signals cell death from the nucleus

6 / 521

0.037

5.89e-04

0.023

71 / 633

0.053

Co-occurrence

 MECP2 regulates transcription of neuronal ligands

2 / 13

9.25e-04

3.18e-04

0.036

2 / 8

6.68e-04

 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)

2 / 17

0.001

5.41e-04

0.036

2 / 20

0.002

 NRIF signals cell death from the nucleus

2 / 18

0.001

6.06e-04

0.036

4 / 7

5.84e-04

 Amyloid fiber formation

3 / 88

0.006

7.15e-04

0.036

16 / 33

0.003

 Neurodegenerative diseases

2 / 30

0.002

0.002

0.056

2 / 22

0.002

COALS

 Plasma lipoprotein assembly

3 / 30

0.002

4.18e-05

0.01

8 / 19

0.002

 MECP2 regulates transcription of neuronal ligands

2 / 13

9.25e-04

3.91e-04

0.042

2 / 8

6.68e-04

 HDL assembly

2 / 18

0.001

7.44e-04

0.042

7 / 9

7.51e-04

 NRIF signals cell death from the nucleus

2 / 18

0.001

7.44e-04

0.042

4 / 7

5.84e-04

 Amyloid fiber formation

3 / 88

0.006

9.67e-04

0.044

16 / 33

0.003

Word2Vec

 Transfer of LPS from LBP carrier to CD14

1 / 3

2.13e-04

0.005

0.075

2 / 2

1.67e-04

 NTF3 activates NTRK2 (TRKB) signaling

1 / 4

2.85e-04

0.006

0.075

3 / 3

2.50e-04

 NTF4 activates NTRK2 (TRKB) signaling

1 / 4

2.85e-04

0.006

0.075

3 / 3

2.50e-04

 BDNF activates NTRK2 (TRKB) signaling

1 / 4

2.85e-04

0.006

0.075

3 / 3

2.50e-04

Defective GSS causes glutathione synthetase deficiency (GSS deficiency)

1 / 4

2.85e-04

0.006

0.075

1 / 1

8.34e-05

  1. * False Discovery Rate