Table 1 Characteristics of all children in the Model and Validation groups. The data presented for the Auxological model (a & b) and the Endocrine models (c & d).
a. Model group | b. Validation group | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Variables | Mean | SD | Min | Max | N | Mean | SD | Min | Max | N |
At birth | ||||||||||
Gestational age (weeks) | 39.6 | 1.3 | 37 | 42 | 415 | 39.5 | 1.5 | 37 | 42 | 112 |
Height SDS | -1.33 | 1.29 | -5.8 | 2.0 | 415 | -1.31 | 1.12 | -5.4 | 1.5 | 112 |
Weight SDS | -1.08 | 1.27 | -4.5 | 3.2 | 415 | -1.07 | 1.1 | -4.4 | 2.3 | 112 |
Pretreatment | ||||||||||
Δheight SDS during pretreat yr | 0.01 | 0.18 | -0.5 | 0.6 | 377 | 0.03 | 0.22 | -0.66 | 0.68 | 101 |
GHmax of GH-profile | 42.5 | 28.8 | 3.9 | 235.4 | 188 | 34.0 | 21.3 | 7.6 | 98.1 | 60 |
GHmax during AITT | 28.6 | 24.4 | 1.7 | 229.4 | 387 | 21.9 | 14.5 | 1.4 | 76.1 | 95 |
At GH start | ||||||||||
SEX (min = girls, max = boys) | 93 | 322 | 415 | 33 | 79 | 112 | ||||
Age (yrs) | 8.72 | 2.41 | 3.1 | 13.9 | 415 | 7.88 | 2.19 | 2.8 | 12.2 | 112 |
Height SDS | -2.87 | 0.6 | -5.0 | -1.2 | 415 | -2.77 | 0.53 | -4.2 | -1.6 | 112 |
Weight SDS | -2.56 | 0.94 | -6.2 | 1.8 | 415 | -2.38 | 1.09 | -4.9 | 2.6 | 112 |
Father height SDS | -1.03 | 1.07 | -4.9 | 2.1 | 415 | -0.74 | 1.03 | -3.0 | 1.7 | 112 |
Mother height SDS | -1.31 | 1 | -3.8 | 1.6 | 415 | -0.99 | 0.96 | -3.1 | 1.5 | 112 |
Diff SDS | -2.17 | 0.74 | -5.0 | -0.3 | 415 | -2.29 | 0.72 | -5.1 | 0.2 | 112 |
IGF SDS | -1.11 | 1.55 | -7.4 | 3.0 | 223 | -1.23 | 1.5 | -5.3 | 2.7 | 83 |
Leptin (ng/mL) | 3.48 | 2.37 | 1.0 | 27.8 | 216 | 3.97 | 3.75 | 1.7 | 24.1 | 82 |
During treatment | ||||||||||
GH dose (IU/kg/day) | 0.11 | 0.03 | 0.07 | 0.25 | 415 | 0.11 | 0.02 | 0.08 | 0.2 | 112 |
Change in height SDS 1st yr | 0.75 | 0.3 | 0.1 | 2.3 | 415 | 0.73 | 0.25 | 0.1 | 1.6 | 112 |
Change in height SDS two yrs | 1.18 | 0.44 | 0.2 | 3.0 | 300 | 1.17 | 0.34 | 0.4 | 2.1 | 73 |
c. Model group | d. Validation group | |||||||||
At birth | ||||||||||
Gestational age (weeks) | 39.4 | 1.3 | 37 | 42 | 140 | 39.6 | 1.4 | 37 | 42 | 51 |
Height SDS | -1.77 | 1.35 | -5.8 | 1.9 | 140 | -1.33 | 1.12 | -4.1 | 1.5 | 51 |
Weight SDS | -1.39 | 1.36 | -4.5 | 2.4 | 140 | -1.19 | 1.02 | -3.2 | 1.0 | 51 |
Pretreatment | ||||||||||
Δheight SDS during pretreat yr | 0.07 | 0.17 | -0.5 | 0.6 | 135 | 0.04 | 0.18 | -0.6 | 0.4 | 48 |
GHmax of GH-profile | 44.3 | 28.1 | 9.3 | 235.4 | 140 | 30.6 | 17.3 | 6.4 | 76.1 | 40 |
GHmax during AITT | 37.6 | 22.4 | 3.0 | 124.9 | 113 | 36.7 | 21.9 | 7.6 | 98.1 | 51 |
At GH start | ||||||||||
SEX (min = girls, max = boys) | 32 | 108 | 140 | 18 | 33 | 51 | ||||
Age (yrs) | 8.66 | 2.34 | 3.3 | 12.9 | 140 | 7.88 | 2.05 | 3.4 | 11.9 | 51 |
Height SDS | -2.86 | 0.61 | -4.8 | -1.7 | 140 | -2.80 | 0.56 | -4.2 | -2.0 | 51 |
Weight SDS | -2.61 | 1.02 | -5.3 | 1.6 | 140 | -2.46 | 1.11 | -4.9 | 1.3 | 51 |
Father height SDS | -1.04 | 1.08 | -4.9 | 1.9 | 140 | -0.71 | 0.91 | -2.2 | 1.7 | 51 |
Mother height SDS | -1.39 | 1.04 | -3.8 | 1.2 | 140 | -0.88 | 0.87 | -2.6 | 1.0 | 51 |
Diff SDS | -2.12 | 0.74 | -4.6 | -0.4 | 140 | -2.37 | 0.77 | -5.1 | -0.8 | 51 |
IGF SDS | -0.82 | 1.32 | -5.1 | 3.0 | 140 | -1.49 | 1.54 | -5.3 | 1.4 | 51 |
Leptin (ng/mL) | 3.51 | 2.71 | 1.1 | 27.8 | 140 | 3.70 | 3.30 | 1.7 | 21.8 | 51 |
During treatment | ||||||||||
GH dose (IU/kg/day) | 0.12 | 0.04 | 0.07 | 0.25 | 140 | 0.12 | 0.02 | 0.08 | 0.20 | 51 |
Change in height SDS 1st yr | 0.68 | 0.21 | 0.2 | 1.4 | 140 | 0.77 | 0.23 | 0.4 | 1.6 | 51 |
Change in height SDS two yrs | 1.06 | 0.32 | 0.2 | 1.9 | 104 | 1.21 | 0.33 | 0.7 | 2.1 | 34 |